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Notably, immunoblot analysis revealed that TNF induced EAAT3 expression in MTEC-WT cells, while the NF-B inhibitor BMS 345541 suppressed EAAT3 expression in MTEC-KO cells (Fig

Normally inactive in the cytoplasm and bound to the inhibitory protein IB, NF-B becomes active when IB degrades, facilitating its translocation to the nucleus where it promotes the expression of pro-inflammatory genes ( Additionally, Curcuma longae Rhizoma modulates other significant inflammatory pathways including the Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) enzymes that catalyze the production of major inflammatory mediators like prostaglandins and leukotrienes ( 2.2 Anti-oxidant effect Curcuma longae Rhizoma is highly regarded for its robust antioxidant properties, largely attributed to its active metabolite, curcumin or -elemene, and other phytochemicals present in the rhizome ( The antioxidant mechanisms of Curcuma longae Rhizoma are multifaceted

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10.1016/j.cbi.2017.10.021 77 NiederhofferN.SchmidK.SzaboB